Paediatric autoimmune thyroiditis triggered by prior SARS-CoV-2 exposure: a case with transient hashitoxicosis

Post-viral thyroid dysfunction, including autoimmune thyroiditis, may occur after severe acute respiratory syndrome coronavirus 2 infection even in children and should be considered in the differential diagnosis of prolonged febrile or inflammatory syndromes.Hashitoxicosis represents a transient destructive phase of autoimmune thyroiditis and can mimic subacute thyroiditis or other causes of thyrotoxicosis; ultrasound vascularity and antibody profile help differentiate them.Systemic inflammation with hepatic cytolysis or cytopenias may accompany autoimmune thyroid involvement, reflecting multi-organ immune activation rather than isolated endocrine disease.Thyroid function testing (thyroid-stimulating hormone, free thyroxine, antibodies) should be included in the evaluation of patients, children or adults, with unexplained post-viral symptoms or abnormal inflammatory profiles.

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Publication Details

Journal
European Journal of Case Reports in Internal Medicine
Published
2025-12-05
DOI
https://doi.org/10.12890/2025_006006
Primary Topic
Thyroid Disorders and Treatments
Type
article
Field-Weighted Citation Impact
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article

Paediatric autoimmune thyroiditis triggered by prior SARS-CoV-2 exposure: a case with transient hashitoxicosis

Victoria Bîrluțiu, Louis R. Caplan, Maria Elena Cocuz, Ligia Rodina et al.
European Journal of Case Reports in Internal Medicine
Thyroid Disorders and Treatments
article

Paediatric autoimmune thyroiditis triggered by prior SARS-CoV-2 exposure: a case with transient hashitoxicosis

Victoria Bîrluțiu, Louis R. Caplan, Maria Elena Cocuz, Ligia Rodina, Elena-Vanda Ciudin
article en

Abstract

Post-viral thyroid dysfunction, including autoimmune thyroiditis, may occur after severe acute respiratory syndrome coronavirus 2 infection even in children and should be considered in the differential diagnosis of prolonged febrile or inflammatory syndromes.Hashitoxicosis represents a transient destructive phase of autoimmune thyroiditis and can mimic subacute thyroiditis or other causes of thyrotoxicosis; ultrasound vascularity and antibody profile help differentiate them.Systemic inflammation with hepatic cytolysis or cytopenias may accompany autoimmune thyroid involvement, reflecting multi-organ immune activation rather than isolated endocrine disease.Thyroid function testing (thyroid-stimulating hormone, free thyroxine, antibodies) should be included in the evaluation of patients, children or adults, with unexplained post-viral symptoms or abnormal inflammatory profiles.

European Journal of Case Reports in Internal MedicineVol. 13(1)
Lucian Blaga University of Sibiu (RO), Transylvania University of Brașov (RO)
Openalex Percentile: Top 49%
Thyroid Disorders and Treatments
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