Paediatric autoimmune thyroiditis triggered by prior SARS-CoV-2 exposure: a case with transient hashitoxicosis
Post-viral thyroid dysfunction, including autoimmune thyroiditis, may occur after severe acute respiratory syndrome coronavirus 2 infection even in children and should be considered in the differential diagnosis of prolonged febrile or inflammatory syndromes.Hashitoxicosis represents a transient destructive phase of autoimmune thyroiditis and can mimic subacute thyroiditis or other causes of thyrotoxicosis; ultrasound vascularity and antibody profile help differentiate them.Systemic inflammation with hepatic cytolysis or cytopenias may accompany autoimmune thyroid involvement, reflecting multi-organ immune activation rather than isolated endocrine disease.Thyroid function testing (thyroid-stimulating hormone, free thyroxine, antibodies) should be included in the evaluation of patients, children or adults, with unexplained post-viral symptoms or abnormal inflammatory profiles.
Authors
- Victoria Bîrluțiu (ORCID: https://orcid.org/0000-0001-7391-3394)
- Louis R. Caplan (ORCID: https://orcid.org/0000-0002-7507-9521)
- Maria Elena Cocuz (ORCID: https://orcid.org/0000-0002-6998-6600)
- Ligia Rodina (ORCID: https://orcid.org/0009-0003-8640-5614)
- Elena-Vanda Ciudin
Institutions
- Lucian Blaga University of Sibiu (RO)
- Transylvania University of Brașov (RO)
Publication Details
- Journal
- European Journal of Case Reports in Internal Medicine
- Published
- 2025-12-05
- DOI
- https://doi.org/10.12890/2025_006006
- Primary Topic
- Thyroid Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00