tsRNA-3040b accumulates R-loop to regulate Trim35 transcription, which leads to disordered glycolysis and promotes PAECs proliferation
This study highlights the role of tsRNA-3040b in promoting PH by influencing glucose metabolism processes. These results offer a new approach to treating PH and suggest that tsRNA-3040b could serve as a potential target for diagnosing PH and related conditions.
Authors
- Ya Xu (ORCID: https://orcid.org/0000-0001-9360-8848)
- Xiaodong Zheng (ORCID: https://orcid.org/0000-0002-6103-9836)
- Yan Xing (ORCID: https://orcid.org/0000-0002-8076-0805)
- Songyue Li (ORCID: https://orcid.org/0000-0001-7161-3881)
- Xu Wang (ORCID: https://orcid.org/0000-0001-6920-0375)
- Xinru Wang (ORCID: https://orcid.org/0009-0001-4446-4961)
- Yibin Zhang (ORCID: https://orcid.org/0000-0002-3872-5125)
- Jingya Zhang (ORCID: https://orcid.org/0000-0002-2657-9802)
- Jing Qi (ORCID: https://orcid.org/0000-0002-5744-5364)
- Xinyue Song (ORCID: https://orcid.org/0000-0002-6831-9750)
- Shengjun Cao
- Jingming Hou (ORCID: https://orcid.org/0000-0002-8964-0359)
Institutions
- Harbin Medical University (CN)
- Daqing City People's Hospital (CN)
- Education Department of Heilongjiang Province (CN)
Publication Details
- Journal
- Cellular & Molecular Biology Letters
- Published
- 2025-12-05
- DOI
- https://doi.org/10.1186/s11658-025-00816-5
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00