Device encapsulated MSCs for adaptive secretome therapy to effectively target ischaemic heart injury
This translational study highlights a clinically viable, minimally invasive method for sustained cardioprotection, harnessing the MSC secretome to address a pivotal gap in current treatments for ischaemic heart disease.
Authors
- Rebecca H. Ritchie (ORCID: https://orcid.org/0000-0002-8610-0058)
- Saba Naghipour (ORCID: https://orcid.org/0000-0001-6624-5674)
- Thomas Loudovaris (ORCID: https://orcid.org/0000-0002-7038-2302)
- Derek J. Hausenloy (ORCID: https://orcid.org/0000-0003-0729-4956)
- Kilian Kelly (ORCID: https://orcid.org/0000-0002-1666-1896)
- Klearchos K. Papas (ORCID: https://orcid.org/0000-0002-4554-0911)
- James J.H. Chong (ORCID: https://orcid.org/0000-0002-5201-4856)
- David W. Greening (ORCID: https://orcid.org/0000-0001-7516-485X)
- Anne M. Kong
- Yali Deng
- Janna Leigh Morrison (ORCID: https://orcid.org/0000-0002-8602-8519)
- Shiang Y. Lim (ORCID: https://orcid.org/0000-0002-0442-3655)
- Jarmon G. Lees (ORCID: https://orcid.org/0000-0002-9259-8657)
- Jack R. T. Darby (ORCID: https://orcid.org/0000-0001-7114-3920)
- Andrew R. Kompa (ORCID: https://orcid.org/0000-0003-1002-2302)
- Tanya Hall
- Cameron Kos
- Jonathon Cross (ORCID: https://orcid.org/0009-0006-3057-8964)
- Robert S. Phang
- Lina Mariana
- Andrew Newcomb
- Ashley Nowland
Institutions
- The University of Sydney (AU)
- University of Arizona (US)
- Baker Heart and Diabetes Institute (AU)
- The University of Melbourne (AU)
- National University of Singapore (SG)
- University of Toronto (CA)
- La Trobe University (AU)
- Hospital for Sick Children (CA)
- Westmead Hospital (AU)
- SA Health (AU)
- Banner - University Medical Center Tucson (US)
- Duke-NUS Medical School (SG)
- SickKids Foundation (CA)
- Westmead Institute for Medical Research (AU)
- National Heart Centre Singapore (SG)
- Australian Centre for Heart Health (AU)
- Io Therapeutics (United States) (US)
- Melbourne Health (AU)
- University College London (GB)
- Monash University (AU)
- St Vincents Institute of Medical Research (AU)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-12-05
- DOI
- https://doi.org/10.1186/s13287-025-04847-9
- Citations
- 1
- Primary Topic
- Tissue Engineering and Regenerative Medicine
- Type
- article
- Field-Weighted Citation Impact
- 2.01