DNA methylation predicts lung function and pulmonary exacerbation in sputum samples from patients with cystic fibrosis
We provide the first longitudinal assessment of genome-wide DNA methylation in a cohort of patient with CF and identify CpG sites that predict clinical traits of key importance for lung disease. The associated genes play a critical role in inflammation or pancreatic endocrine activity. Overall, our results underscore the emerging role of DNA methylation as a key modulator of disease severity in CF.
Authors
- Christelle Reynès (ORCID: https://orcid.org/0000-0001-9536-9051)
- Manuela Pastore (ORCID: https://orcid.org/0000-0002-1887-6380)
- Davide Caimmi (ORCID: https://orcid.org/0000-0003-4481-6194)
- R. Chiron
- Jörg Tost (ORCID: https://orcid.org/0000-0002-2683-0817)
- Florence Busato (ORCID: https://orcid.org/0000-0002-1459-7712)
- Albertina De Sario (ORCID: https://orcid.org/0000-0002-9997-1645)
- Isabelle Vachier (ORCID: https://orcid.org/0000-0003-2730-5165)
- Mireille Claustres (ORCID: https://orcid.org/0000-0002-8659-2646)
- Fanny Pineau (ORCID: https://orcid.org/0000-0002-3131-9650)
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Université de Montpellier (FR)
- Commissariat à l'Énergie Atomique et aux Énergies Alternatives (FR)
- Physiologie et Médecine Expérimentale du Coeur et des Muscles (FR)
- Centre Hospitalier Universitaire de Montpellier (FR)
- Direction de la Recherche Fondamentale (FR)
- Institute for Neurosciences of Montpellier (FR)
Publication Details
- Journal
- Clinical Epigenetics
- Published
- 2025-12-05
- DOI
- https://doi.org/10.1186/s13148-025-02032-6
- Primary Topic
- Cystic Fibrosis Research Advances
- Type
- article
- Field-Weighted Citation Impact
- 0.00