Cu–Fe <sub>3</sub> O <sub>4</sub> Nanozyme Reverses Age-Impaired Alveolar Healing via Reactive Oxygen–Nitrogen Species Scavenging and Mitophagy Reactivation
Age-related decline in bone healing capacity poses significant challenges for tooth extraction recovery in the elderly. Elevated reactive oxygen-nitrogen species (RONS) and impaired mitophagy drive this pathology. We engineered bimetallic Cu-Fe<sub>3</sub>O<sub>4</sub> nanoclusters with oxygen vacancies (OVs) via hydrothermal synthesis. The abundant oxygen vacancies and bimetallic synergy endow Cu-Fe<sub>3</sub>O<sub>4</sub> with exceptional enzyme-mimicking activity, enabling efficient scavenging of excess RONS and activation of mitophagy in senescent cells in vitro, thereby reversing functional decline. Owing to its excellent biocompatibility and negligible in vivo toxicity, Cu-Fe<sub>3</sub>O<sub>4</sub> accelerates tooth extraction wound healing in aged animal models.
Authors
- Jianyu Cao (ORCID: https://orcid.org/0000-0003-2716-7663)
- Dong Qiu (ORCID: https://orcid.org/0000-0003-4978-2077)
- Yifeng Bian (ORCID: https://orcid.org/0009-0003-3331-2414)
- Ran Qin
- Yongchu Pan (ORCID: https://orcid.org/0000-0002-6899-5994)
- Haobo Lin (ORCID: https://orcid.org/0009-0002-1500-8729)
- Xinyu Hu (ORCID: https://orcid.org/0000-0002-9739-5613)
- Chang Sun (ORCID: https://orcid.org/0000-0002-2425-9485)
- Yuchen Wang (ORCID: https://orcid.org/0000-0002-6710-6710)
- Yifei Du (ORCID: https://orcid.org/0000-0002-2262-5808)
- Zheng Cheng
- Yongbao Ruan
- Jingxuan Cang
Institutions
- Shanghai Stomatological Hospital (CN)
- Yancheng Third People's Hospital (CN)
- Yancheng Second People's Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Langmuir
- Published
- 2025-12-05
- DOI
- https://doi.org/10.1021/acs.langmuir.5c04365
- Primary Topic
- Advanced Nanomaterials in Catalysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00