Quantifying interplay effects in lung cancer IMPT: a comprehensive analysis of treatment planning parameter sensitivity
A systematic analysis was conducted in this study on the impact of spot size, LS, SS, layer repainting, and ring structure on the 4D robustness of IMPT plans for lung cancer patients. These five strategies demonstrated that beam spot size and layer spacing affected plan robustness, while spot spacing had relatively minor influence on robustness. The repainting technology can mitigate the interplay effect caused by respiratory motion. The application of ring structures affected the dose distribution of the moving target.
Authors
- Ian Li (ORCID: https://orcid.org/0000-0002-1438-8830)
- Tianyuan Dai (ORCID: https://orcid.org/0009-0005-5493-6933)
- Shuting Wang (ORCID: https://orcid.org/0000-0003-4137-5821)
- Yong Yin (ORCID: https://orcid.org/0000-0001-6768-4476)
- Ruozheng Wang (ORCID: https://orcid.org/0000-0002-0524-1212)
- Xiaoying Fan
Institutions
- Shandong University of Traditional Chinese Medicine (CN)
- Xinjiang Medical University (CN)
- Shandong Tumor Hospital (CN)
- Tumor Hospital of Xinjiang Medical University (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- BMC Cancer
- Published
- 2025-12-05
- DOI
- https://doi.org/10.1186/s12885-025-15416-x
- Citations
- 1
- Primary Topic
- Advanced Radiotherapy Techniques
- Type
- article
- Field-Weighted Citation Impact
- 1.88