Analysis of immune-related biomarkers in amniotic fluid embolism by sequencing data and bioinformatics
We have provided valuable peripheral blood sequencing data from AFE patients and healthy controls. Through bioinformatics analysis, we identified two immune-related biomarkers: MMP9 and PPBP and systematically examines their biological significance through immune infiltration profiling, gene set enrichment, regulatory network construction, and pharmacological association studies. This study provides preliminary evidence for the diagnostic potential of these two markers for AFE and offers new insights for research into the immune response associated with AFE.
Authors
- Yang Li (ORCID: https://orcid.org/0009-0004-3179-3944)
- Shaofan Hu (ORCID: https://orcid.org/0000-0002-8592-1866)
- Rui Zhang (ORCID: https://orcid.org/0000-0002-8655-4017)
- Jing Luo (ORCID: https://orcid.org/0000-0001-5821-5846)
- Yinjia Wang
- Jianjun Liu (ORCID: https://orcid.org/0000-0002-3255-3019)
- Ying Song (ORCID: https://orcid.org/0000-0002-7367-1150)
- Yongqiong Yang
- Jitao Ma (ORCID: https://orcid.org/0000-0002-9007-4024)
Institutions
- Kunming Medical University (CN)
- Yunnan Maternal and Child Health (CN)
- The First Hospital of Kunming (CN)
- First Affiliated Hospital of Kunming Medical University (CN)
Publication Details
- Journal
- BMC Pregnancy and Childbirth
- Published
- 2025-12-05
- DOI
- https://doi.org/10.1186/s12884-025-08534-8
- Primary Topic
- Maternal and fetal healthcare
- Type
- article
- Field-Weighted Citation Impact
- 0.00