Research progress in molecular targeted therapy for inflammatory bowel disease

The global burden of IBD continues to rise, particularly in newly industrialized regions such as China, where urbanization and lifestyle changes have accelerated incidence rates. Conventional therapies-aminosalicylates, corticosteroids, and traditional immunomodulators-often fail to sustain long-term remission in moderate-to-severe cases and are associated with cumulative toxicities such as bone marrow suppression and organ injury, underscoring an urgent need for precision-based interventions. This review synthesizes recent advances in molecular targeted therapy for IBD, clarifies mechanisms underlying key targets, and evaluates the efficacy and safety of emerging agents to inform clinical decision-making and future research. We performed a comprehensive literature search (2014-2025) in PubMed, Embase, and the Cochrane Library using keywords such as "inflammatory bowel disease," "molecular targeted therapy," "TNF inhibitors," "JAK inhibitors," and "biomarkers." This search identified over 500 clinical trials, meta-analyses, and mechanistic studies. The evidence highlights the transformative role of targeted agents in increasing remission rates while revealing variability in response across patient subgroups and uncertainties regarding long-term safety. Core issues include optimizing therapeutic sequencing to prevent primary non-response and secondary loss of response, validating and integrating biomarkers (e.g., miR-21) for stratified treatment, and balancing efficacy of multi-pathway modulators against risks such as opportunistic infections and cardiovascular events.