Efflux-mediated multidrug resistance mechanism in <i>Trichophyton indotineae</i> and <i>Trichophyton rubrum;</i> role of ABC transporters and MFS gene
Our study provides valuable insights into the expression patterns of efflux-pump genes in Trichophyton spp. and their role in antifungal resistance. TiTR-WT predominantly upregulate MDR1, MDR2, MFS1, while SE-mutant strains compensate via SE gene overexpression in T. indotineae.
Authors
- Kāmini Walia
- Anup Ghosh (ORCID: https://orcid.org/0000-0002-0341-6680)
- Shivaprakash Mandya Rudramurthy (ORCID: https://orcid.org/0000-0002-9097-9253)
- Arunaloke Chakrabarti (ORCID: https://orcid.org/0000-0003-1555-3807)
- Sunil Dogra (ORCID: https://orcid.org/0000-0001-9912-0085)
- Sanjeev Handa (ORCID: https://orcid.org/0000-0002-1486-7161)
- Dipika Shaw (ORCID: https://orcid.org/0000-0003-0436-7726)
- Sourav Agnihotri
- Harsimran Kaur (ORCID: https://orcid.org/0000-0002-4871-8113)
- Sheetal Thakur
- Tarun Narang
Institutions
- Indian Council of Medical Research (IN)
- Post Graduate Institute of Medical Education and Research (IN)
Publication Details
- Journal
- Journal of Antimicrobial Chemotherapy
- Published
- 2025-11-06
- DOI
- https://doi.org/10.1093/jac/dkaf434
- Primary Topic
- Nail Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00