Utility of peripheral blood testing for detection and surveillance of clonal hematopoiesis in predisposed individuals
In this study, 108 pediatric patients with bone marrow (BM) failure and leukemia predisposition were evaluated for presence of clonal hematopoiesis in peripheral blood (PB) and BM. Robust PB-BM concordance for mutations but decreased sensitivity in PB for chromosomal abnormalities was found.
Authors
- Alyssa L. Kennedy (ORCID: https://orcid.org/0000-0001-7948-5933)
- Guolian Kang
- Sushree Sangita Sahoo (ORCID: https://orcid.org/0000-0001-7031-2219)
- Marcin W. Włodarski (ORCID: https://orcid.org/0000-0001-6638-9643)
- Rohith Jesudas (ORCID: https://orcid.org/0000-0002-9481-2581)
- Lili Kotmayer (ORCID: https://orcid.org/0000-0002-5089-7659)
- Georgios E. Christakopoulos (ORCID: https://orcid.org/0000-0001-7100-658X)
- Michelle Boals
- Nathan Gray (ORCID: https://orcid.org/0009-0000-8030-9670)
- Sara E. Lewis (ORCID: https://orcid.org/0000-0001-8119-7076)
- Lucilla Pizzo (ORCID: https://orcid.org/0000-0001-9325-7283)
- Ulrike M. Reiss (ORCID: https://orcid.org/0000-0002-2258-3687)
- Enrico Attardi (ORCID: https://orcid.org/0009-0008-4801-5048)
- Maria Teresa Voso (ORCID: https://orcid.org/0000-0002-6164-4761)
- Passant Shaker (ORCID: https://orcid.org/0000-0001-9750-9310)
- Erica Andersen (ORCID: https://orcid.org/0000-0002-7205-0600)
- Senthil Velan Bhoopalan (ORCID: https://orcid.org/0000-0002-1402-6549)
- Joseph H. Oved (ORCID: https://orcid.org/0000-0002-1129-5129)
- Peng Li (ORCID: https://orcid.org/0000-0003-4711-362X)
- Richa Sharma (ORCID: https://orcid.org/0000-0003-0462-661X)
- Jian Zhao
- Clifford M. Takemoto (ORCID: https://orcid.org/0000-0002-2832-6884)
Institutions
- University of Rome Tor Vergata (IT)
- St. Jude Children's Research Hospital (US)
- Cleveland Clinic (US)
- Memorial Sloan Kettering Cancer Center (US)
- University of Utah (US)
- Columbia University Irving Medical Center (US)
- ARUP Laboratories (United States) (US)
Publication Details
- Journal
- Blood
- Published
- 2025-12-03
- DOI
- https://doi.org/10.1182/blood.2024028042
- Primary Topic
- Acute Myeloid Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00