Abiraterone Acetate Triggers <scp>ER</scp> Stress‐Mediated Androgen Receptor Suppression via <scp>PERK</scp> / <scp>ATF4</scp> / <scp>CHOP</scp> Signaling in Prostate Cancer
AA induces ER stress, leading to transcriptional downregulation of the AR and suppression of PCa cell viability and proliferation. Targeting the PERK pathway may enhance AA efficacy in AR-driven PCa.
Authors
- Ceyhan Hacıoğlu (ORCID: https://orcid.org/0000-0002-0993-6118)
- Ekrem Başaran (ORCID: https://orcid.org/0000-0001-8319-512X)
Institutions
- Düzce Üniversitesi (TR)
Publication Details
- Journal
- International Journal of Urology
- Published
- 2025-12-03
- DOI
- https://doi.org/10.1111/iju.70304
- Citations
- 1
- Primary Topic
- Prostate Cancer Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 1.52