“Who ‘nose’ when a seizure will happen?” Prodromal olfactory loss as a first clinical indicator of seizure activity in temporal lobe epilepsy
This study is the first to quantitatively link prodromal olfactory dysfunction to seizure onset in TLE, identifying it as a potentially accessible, low-cost, non-invasive biomarker. These findings suggest a novel adjunct for seizure forecasting, and support future development of olfaction-based prediction strategies. Larger scale studies are warranted to validate these results and investigate underlying mechanisms connecting olfactory circuits with ictogenesis.
Authors
- Manal F Alshammari (ORCID: https://orcid.org/0009-0006-5878-9202)
- Ayman A. AbdelHamid (ORCID: https://orcid.org/0000-0001-8489-5347)
- Sasha Dionisio (ORCID: https://orcid.org/0000-0003-0870-6094)
- Jackie Y. Ying (ORCID: https://orcid.org/0000-0001-6938-2113)
- Gamal Mohamed (ORCID: https://orcid.org/0000-0003-3675-6806)
- Hasan Mohammed Daghriri (ORCID: https://orcid.org/0009-0007-0125-559X)
- Muteb Mohammed Aldawsari (ORCID: https://orcid.org/0009-0006-0118-7358)
Institutions
- King Fahd University of Petroleum and Minerals (SA)
- Alfaisal University (SA)
- King Faisal Specialist Hospital & Research Centre (SA)
Publication Details
- Journal
- Epileptic Disorders
- Published
- 2025-12-04
- DOI
- https://doi.org/10.1002/epd2.70143
- Primary Topic
- Olfactory and Sensory Function Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00