Trial of Pegcetacoplan in C3 Glomerulopathy and Immune-Complex MPGN

Pegcetacoplan resulted in a significantly greater reduction in proteinuria than placebo among patients with C3 glomerulopathy or primary immune-complex MPGN. (Funded by Apellis Pharmaceuticals and Sobi [Swedish Orphan Biovitrum]; VALIANT ClinicalTrials.gov number, NCT05067127.).

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Institutions

Publication Details

Journal
New England Journal of Medicine
Published
2025-12-03
DOI
https://doi.org/10.1056/nejmoa2501510
Citations
15
Primary Topic
Complement system in diseases
Type
article
Field-Weighted Citation Impact
11.96
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article

Trial of Pegcetacoplan in C3 Glomerulopathy and Immune-Complex MPGN

Johan Szamosi, Luis López Lázaro, Andrew S. Bomback, Daniel Zecher et al.
15 citations
New England Journal of Medicine
Complement system in diseases
11.96
article

Trial of Pegcetacoplan in C3 Glomerulopathy and Immune-Complex MPGN

Johan Szamosi, Luis López Lázaro, Andrew S. Bomback, Daniel Zecher, Giuseppe Remuzzi, Nils Kinnman, Seung Hyeok Han, Larry A. Greenbaum, Pascal Deschatelets, Carla Nester, Antonio Mastrangelo, Nicole C. A. J. van de Kar, Moglie Le Quintrec, Bradley P. Dixon, Yahsou Delmas, Marina Vivarelli, Daniel P. Gale, Dean Wallace, Masashi Mizuno, Nicole M. Isbel, Zhongshen Wang, Gema Ariceta, Lydia Abad‐Franch, Christoph P. B. Licht, Matthew C. Pickering, Fádi Fakhouri, Maria Izabel Neves de Holanda, Patrick D. Walker, Cedric Francois, Li Li
article en
15 citations

Abstract

Pegcetacoplan resulted in a significantly greater reduction in proteinuria than placebo among patients with C3 glomerulopathy or primary immune-complex MPGN. (Funded by Apellis Pharmaceuticals and Sobi [Swedish Orphan Biovitrum]; VALIANT ClinicalTrials.gov number, NCT05067127.).

New England Journal of MedicineVol. 393(22)
Radboud University Nijmegen (NL), Emory University (US), The University of Queensland (AU), University of Toronto (CA), Yonsei University (KR), Mario Negri Institute for Pharmacological Research (IT), Columbia University Irving Medical Center (US), Great Ormond Street Hospital (GB), Hospital for Sick Children (CA), Princess Alexandra Hospital (AU), Radboud University Medical Center (NL), Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT), University Hospital Regensburg (DE), Arkana Laboratories (US), University of Iowa Stead Family Children’s Hospital (US), Bordeaux Population Health (FR), Amalia Kinderziekenhuis (NL), Swedish Orphan Biovitrum (United States) (US), Apellis Pharmaceuticals (United States) (US), Bambino Gesù Children's Hospital (IT), Hospital Geral de Bonsucesso (BR), Vall d'Hebron Hospital Universitari (ES), Hôpital Lapeyronie (FR), Swedish Orphan Biovitrum (Sweden) (SE), SickKids Foundation (CA), Children's Healthcare of Atlanta (US), Istituti di Ricovero e Cura a Carattere Scientifico (IT), Royal Manchester Children's Hospital (GB), University College London (GB), Imperial College London (GB), Nagoya University (JP), University of Colorado Denver (US), University of Lausanne (CH)
Openalex Percentile: Top 1%
Complement system in diseases
11.96
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