Trial of Pegcetacoplan in C3 Glomerulopathy and Immune-Complex MPGN
Pegcetacoplan resulted in a significantly greater reduction in proteinuria than placebo among patients with C3 glomerulopathy or primary immune-complex MPGN. (Funded by Apellis Pharmaceuticals and Sobi [Swedish Orphan Biovitrum]; VALIANT ClinicalTrials.gov number, NCT05067127.).
Authors
- Johan Szamosi
- Luis López Lázaro (ORCID: https://orcid.org/0000-0003-0620-6133)
- Andrew S. Bomback (ORCID: https://orcid.org/0000-0001-5449-1667)
- Daniel Zecher (ORCID: https://orcid.org/0000-0002-2123-0310)
- Giuseppe Remuzzi (ORCID: https://orcid.org/0000-0002-6194-3446)
- Nils Kinnman
- Seung Hyeok Han (ORCID: https://orcid.org/0000-0001-7923-5635)
- Larry A. Greenbaum (ORCID: https://orcid.org/0000-0002-2490-021X)
- Pascal Deschatelets (ORCID: https://orcid.org/0009-0001-0123-5528)
- Carla Nester (ORCID: https://orcid.org/0000-0002-0629-7576)
- Antonio Mastrangelo (ORCID: https://orcid.org/0000-0001-5700-7439)
- Nicole C. A. J. van de Kar (ORCID: https://orcid.org/0000-0002-1990-1189)
- Moglie Le Quintrec (ORCID: https://orcid.org/0000-0002-5857-1207)
- Bradley P. Dixon (ORCID: https://orcid.org/0000-0003-3704-0922)
- Yahsou Delmas (ORCID: https://orcid.org/0000-0002-5814-3122)
- Marina Vivarelli (ORCID: https://orcid.org/0000-0002-2448-1959)
- Daniel P. Gale (ORCID: https://orcid.org/0000-0002-9170-1579)
- Dean Wallace
- Masashi Mizuno (ORCID: https://orcid.org/0000-0002-6603-1446)
- Nicole M. Isbel (ORCID: https://orcid.org/0000-0002-9566-7179)
- Zhongshen Wang
- Gema Ariceta
- Lydia Abad‐Franch
- Christoph P. B. Licht (ORCID: https://orcid.org/0000-0003-4168-3277)
- Matthew C. Pickering (ORCID: https://orcid.org/0000-0002-1153-0192)
- Fádi Fakhouri (ORCID: https://orcid.org/0000-0001-5390-8002)
- Maria Izabel Neves de Holanda
- Patrick D. Walker
- Cedric Francois
- Li Li (ORCID: https://orcid.org/0000-0002-9428-1960)
Institutions
- Radboud University Nijmegen (NL)
- Emory University (US)
- The University of Queensland (AU)
- University of Toronto (CA)
- Yonsei University (KR)
- Mario Negri Institute for Pharmacological Research (IT)
- Columbia University Irving Medical Center (US)
- Great Ormond Street Hospital (GB)
- Hospital for Sick Children (CA)
- Princess Alexandra Hospital (AU)
- Radboud University Medical Center (NL)
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
- University Hospital Regensburg (DE)
- Arkana Laboratories (US)
- University of Iowa Stead Family Children’s Hospital (US)
- Bordeaux Population Health (FR)
- Amalia Kinderziekenhuis (NL)
- Swedish Orphan Biovitrum (United States) (US)
- Apellis Pharmaceuticals (United States) (US)
- Bambino Gesù Children's Hospital (IT)
- Hospital Geral de Bonsucesso (BR)
- Vall d'Hebron Hospital Universitari (ES)
- Hôpital Lapeyronie (FR)
- Swedish Orphan Biovitrum (Sweden) (SE)
- SickKids Foundation (CA)
- Children's Healthcare of Atlanta (US)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Royal Manchester Children's Hospital (GB)
- University College London (GB)
- Imperial College London (GB)
- Nagoya University (JP)
- University of Colorado Denver (US)
- University of Lausanne (CH)
Publication Details
- Journal
- New England Journal of Medicine
- Published
- 2025-12-03
- DOI
- https://doi.org/10.1056/nejmoa2501510
- Citations
- 15
- Primary Topic
- Complement system in diseases
- Type
- article
- Field-Weighted Citation Impact
- 11.96