Succinylation of CTBP1 Mediated by SIRT5 Suppresses MAT1A Expression to Promote the Progression of HCC
Our study reveals that SIRT5-mediated CTBP1 succinylation drives HCC progression through MAT1A suppression, establishing a novel regulatory axis with therapeutic potential for HCC treatment.
Authors
- Shangshang Li
- Guang Xiu Lu (ORCID: https://orcid.org/0000-0002-2268-1033)
- Zhengcai Qiu (ORCID: https://orcid.org/0009-0006-4235-4204)
- Qipeng Wang (ORCID: https://orcid.org/0009-0000-2175-3341)
- Jing Han
Institutions
- Nanjing University of Chinese Medicine (CN)
- Liuyang City Maternal and Child Health Hospital (CN)
Publication Details
- Journal
- Cellular Physiology and Biochemistry
- Published
- 2025-12-01
- DOI
- https://doi.org/10.33594/000000832
- Primary Topic
- Sirtuins and Resveratrol in Medicine
- Type
- article
- Field-Weighted Citation Impact
- 0.00