Pancreatic Cancer Organoids Recapitulate Chemotherapy Response and Identify a Potent Cytotoxic T-Cell Population
We confirm the feasibility of generating PDOs within a clinically relevant time frame and provide evidence of their utility for advancing therapeutic success in PDAC.
Authors
- Renee R. Anderko (ORCID: https://orcid.org/0000-0003-1964-3404)
- Asmita Chopra (ORCID: https://orcid.org/0000-0002-5908-3993)
- Pranav Murthy (ORCID: https://orcid.org/0000-0002-4356-5170)
- Aatur Dilip Singhi (ORCID: https://orcid.org/0000-0003-3930-7096)
- Michael T. Lotze (ORCID: https://orcid.org/0000-0003-3988-5419)
- Robbie B. Mailliard (ORCID: https://orcid.org/0000-0001-5501-503X)
- Alessandro Paniccia (ORCID: https://orcid.org/0000-0001-7047-1711)
- Amer H. Zureikat (ORCID: https://orcid.org/0000-0002-7800-5464)
- Siele Ceuppens (ORCID: https://orcid.org/0009-0001-8628-1987)
- Alexandra E Bowman (ORCID: https://orcid.org/0009-0005-3295-2844)
- Nikhil V Tirukkovalur (ORCID: https://orcid.org/0009-0004-3912-9204)
- Kenneth K. Lee (ORCID: https://orcid.org/0000-0003-0221-7310)
- P. Bala Krishna Murthy (ORCID: https://orcid.org/0009-0001-9053-6356)
Institutions
- University of Pittsburgh (US)
- UPMC Hillman Cancer Center (US)
- University of Pittsburgh Medical Center (US)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2025-12-04
- DOI
- https://doi.org/10.1158/1078-0432.ccr-25-1110
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 0.00