<i>In vitro</i> exebacase (CF-301) activity against methicillin-susceptible or methicillin-resistant <i>Staphylococcus aureus</i> and coagulase-negative staphylococci strains isolated from patients with infective endocarditis
Exebacase activity was independent of methicillin resistance and consistently higher against S. aureus than S. epidermidis. Further research is warranted to explore lysins in combination against staphylococcal infections.
Authors
- María-Alexandra Cañas (ORCID: https://orcid.org/0000-0002-0521-7204)
- Bárbara Vidal (ORCID: https://orcid.org/0000-0003-4303-0851)
- Andrés Perissinotti (ORCID: https://orcid.org/0000-0003-4190-2425)
- Raymond Schuch (ORCID: https://orcid.org/0000-0003-4324-573X)
- Asunción Moreno (ORCID: https://orcid.org/0000-0002-5850-5007)
- Eduard Quintana (ORCID: https://orcid.org/0000-0002-5386-7463)
- Carlos Falces (ORCID: https://orcid.org/0000-0002-3483-3786)
- José Marı́a Tolosana (ORCID: https://orcid.org/0000-0002-1215-3472)
- José María Miró (ORCID: https://orcid.org/0000-0001-8057-7755)
- Elena Sandoval (ORCID: https://orcid.org/0000-0002-4242-5133)
- Cristina García de la Mària (ORCID: https://orcid.org/0000-0002-0585-9469)
- Jaume Llopis
- Javier García‐González
- Marta Hernández-Meneses
- Filip Krivak
Institutions
- Instituto de Salud Carlos III (ES)
- Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (ES)
- ContraFect (United States) (US)
- Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
- Universitat de Barcelona (ES)
Publication Details
- Journal
- Journal of Antimicrobial Chemotherapy
- Published
- 2025-11-07
- DOI
- https://doi.org/10.1093/jac/dkaf435
- Primary Topic
- Antimicrobial Resistance in Staphylococcus
- Type
- article
- Field-Weighted Citation Impact
- 0.00