Interleukin-8-induced tumor self-rampart spatially confines oncolytic virotherapy in glioblastoma
Glioblastoma mounts a spatial self-protective defense through IL-8-driven TSR formation that restricts oncolytic virus spread. IL-8 functions as both a pharmacodynamic biomarker and a therapeutic target, and its inhibition provides a rational strategy to overcome resistance and optimize GBM virotherapy.
Authors
- Bin Liu (ORCID: https://orcid.org/0000-0002-5051-8006)
- Houshi Xu (ORCID: https://orcid.org/0000-0002-2878-0913)
- Shi Yan (ORCID: https://orcid.org/0000-0001-5939-0718)
- Qisheng Tang (ORCID: https://orcid.org/0000-0003-2954-2797)
- Kang-jian Zhang
- Huihui Chai (ORCID: https://orcid.org/0000-0001-7292-8586)
- Yi‐Fang Ping (ORCID: https://orcid.org/0000-0002-0699-8401)
- Yongfen Xu (ORCID: https://orcid.org/0000-0002-2845-7753)
- Shan Jiang (ORCID: https://orcid.org/0000-0003-1015-126X)
- Zhirui Zhou
- Maoyuan Sun (ORCID: https://orcid.org/0009-0003-1247-182X)
- Zanyi Wu
- Yong Teng (ORCID: https://orcid.org/0000-0002-1856-7289)
- Xin Wang
- Bojie Yang
- Zhen Li (ORCID: https://orcid.org/0000-0003-0333-7699)
- Jiawen Chen (ORCID: https://orcid.org/0000-0001-7101-3034)
- Yue Wang (ORCID: https://orcid.org/0000-0003-0802-1140)
- Liangfu Zhou (ORCID: https://orcid.org/0000-0002-0675-7720)
- Tianwen Li (ORCID: https://orcid.org/0000-0002-6979-8220)
- Zhen Fan (ORCID: https://orcid.org/0000-0002-7485-8179)
- Zhifeng Shi (ORCID: https://orcid.org/0000-0003-1719-0456)
- Yulai Zeng
- Ruize Zhu
- Yun Guan
- Wu Ping
Institutions
- Fujian Medical University (CN)
- Zhejiang Sci-Tech University (CN)
- Army Medical University (CN)
- Chinese Academy of Sciences (CN)
- Fudan University (CN)
- National Institute of Neurological Disorders and Stroke (US)
- Shanghai Institute of Materia Medica (CN)
- First Affiliated Hospital of Fujian Medical University (CN)
- Southwest Hospital (CN)
- Huashan Hospital (CN)
Publication Details
- Journal
- Neuro-Oncology
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1093/neuonc/noaf276
- Primary Topic
- Virus-based gene therapy research
- Type
- article
- Field-Weighted Citation Impact
- 0.00