PDK4 suppresses high glucose-induced microglial ferroptosis by restricting pro-ferroptotic PUFA biosynthesis
PDK4 is a critical regulator of HG-induced microglial ferroptosis, thereby bridging hyperglycemia-induced metabolic dysfunction and neurodegeneration. Our findings nominate PDK4 as a promising therapeutic target for diabetes-linked neurodegenerative diseases.
Authors
- Changhong Tan (ORCID: https://orcid.org/0000-0002-8910-701X)
- Yuke Zhong (ORCID: https://orcid.org/0000-0001-8632-1101)
- Zhihui Liu (ORCID: https://orcid.org/0000-0001-7136-8150)
- Ying Liu (ORCID: https://orcid.org/0000-0003-0634-8158)
- Xi Liu (ORCID: https://orcid.org/0000-0003-3142-7843)
- Lifen Chen (ORCID: https://orcid.org/0000-0003-3355-1338)
- Jiahao Wei
- Huahua Su (ORCID: https://orcid.org/0009-0007-6653-6536)
Institutions
- Dalian Medical University (CN)
- Second Affiliated Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Neuroreport
- Published
- 2025-11-28
- DOI
- https://doi.org/10.1097/wnr.0000000000002234
- Citations
- 2
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 3.04