The metabolite ILA of Akkermansia muciniphila improves AP-related intestinal injury by targeting and inhibiting CASP3 activity
We revealed that ILA, derived from live AKK, may act as a novel endogenous agonist for CASP3. ILA may serve as a new potential treatment method for intestinal injury in AP after successfully translating its efficacy into clinical practice.
Authors
- Xiaoyong Gong (ORCID: https://orcid.org/0000-0002-0346-5677)
- Zhi‐Wang Li (ORCID: https://orcid.org/0000-0003-1623-8059)
- Jinghu Yu (ORCID: https://orcid.org/0000-0002-3763-2509)
- Qinyi Guan (ORCID: https://orcid.org/0009-0000-0858-8986)
- Zhiming Zhang (ORCID: https://orcid.org/0000-0001-5746-9203)
- Le Li (ORCID: https://orcid.org/0000-0002-4999-2288)
- Bo Li (ORCID: https://orcid.org/0000-0002-7767-2732)
- Tao Li (ORCID: https://orcid.org/0000-0001-8958-1355)
- Jiayi He (ORCID: https://orcid.org/0000-0002-0816-2771)
- Peiyu Li (ORCID: https://orcid.org/0000-0002-1001-7485)
- Yi Cui (ORCID: https://orcid.org/0000-0002-7649-8664)
- Shuqi Wu (ORCID: https://orcid.org/0000-0001-6483-4782)
- Xingui Dai (ORCID: https://orcid.org/0000-0002-2931-6549)
Institutions
- Chenzhou First People's Hospital (CN)
- First Affiliated Hospital of Jinan University (CN)
- Xiangnan University (CN)
- University of South China (CN)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-12-05
- DOI
- https://doi.org/10.3389/fmicb.2025.1669383
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00