Multimodal approach to characterize surgically removed epileptogenic zone from patients with focal drug‐resistant epilepsy: From operating room to wet lab
We developed a new protocol for collecting and studying brain tissue removed during epilepsy surgery. By keeping the tissue alive and analyzing it with multiple techniques-such as imaging, electrophysiology, and molecular biology-we can better understand how epilepsy develops. This approach will help doctors identify treatment targets more precisely and improve diagnosis and care for people with drug-resistant epilepsy.
Authors
- Tarja Malm (ORCID: https://orcid.org/0000-0002-9530-7472)
- Ilya Belevich (ORCID: https://orcid.org/0000-0003-2190-4909)
- Nataliia Novosolova (ORCID: https://orcid.org/0000-0003-1248-165X)
- Jokitalo Eija
- Antti Huotarinen (ORCID: https://orcid.org/0000-0002-7212-5780)
- Omar Narvaez (ORCID: https://orcid.org/0000-0002-1881-5983)
- Jussi Tohka (ORCID: https://orcid.org/0000-0002-1048-5860)
- Reetta Kälviäinen (ORCID: https://orcid.org/0000-0003-2935-5131)
- Jenni Kyyriäinen (ORCID: https://orcid.org/0000-0002-8396-6921)
- Anssi Pelkonen (ORCID: https://orcid.org/0000-0002-4154-5686)
- Tuomas Rauramaa (ORCID: https://orcid.org/0000-0002-2250-327X)
- П. А. Абушик (ORCID: https://orcid.org/0000-0001-5731-4527)
- Liudmila Saveleva (ORCID: https://orcid.org/0000-0002-4467-7131)
- Vera Lezhnyova (ORCID: https://orcid.org/0000-0002-0403-2646)
- Alejandra Sierra (ORCID: https://orcid.org/0000-0001-5399-2056)
- Mireia Gómez‐Budia (ORCID: https://orcid.org/0000-0002-2194-2510)
- Leena Jutila (ORCID: https://orcid.org/0000-0002-9600-4406)
- Ville Leinonen (ORCID: https://orcid.org/0000-0002-8660-5742)
- Arto Immonen
- Olli Gröhn (ORCID: https://orcid.org/0000-0003-1372-1651)
- Ekaterina Paasonen (ORCID: https://orcid.org/0000-0003-2365-865X)
- Adriana Della Pietra
- Mastaneh Torkamani‐Azar (ORCID: https://orcid.org/0000-0001-6172-7842)
- Henri Eronen
Institutions
- University of Helsinki (FI)
- University of Eastern Finland (FI)
- Helsinki Institute of Physics (FI)
- Kuopio University Hospital (FI)
Publication Details
- Journal
- Epilepsia Open
- Published
- 2025-12-05
- DOI
- https://doi.org/10.1002/epi4.70174
- Primary Topic
- Epilepsy research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00