Study protocol: Effectiveness of the maternal RSVpreF vaccine by virus type
Our study will identify whether currently circulating RSV genomic variability impacts on rVE. Confirmation of the null hypothesis - that there is no impact of viral genomic variability on rVE - will provide reassurance to policymakers and public health bodies as RSVpreF is rolled out globally. Conversely, an association between RSV type or lineage and decreased vaccine effectiveness will highlight the need for the enhanced comprehensive national and global molecular surveillance of RSV.
Authors
- Chengetai Mpamhanga
- Heather Whitaker (ORCID: https://orcid.org/0000-0001-5833-1863)
- Tiina Talts (ORCID: https://orcid.org/0009-0008-1534-278X)
- Anna Mensah (ORCID: https://orcid.org/0000-0002-3291-3416)
- Nick Andrews (ORCID: https://orcid.org/0000-0001-9966-5093)
- Lynne Ferguson
- Rory Gunson (ORCID: https://orcid.org/0000-0001-9163-492X)
- Chris Robertson (ORCID: https://orcid.org/0000-0001-6848-5241)
- Wei Shen Lim (ORCID: https://orcid.org/0000-0002-7694-3051)
- Thomas Williams (ORCID: https://orcid.org/0000-0002-3866-1344)
- Ross McQueenie (ORCID: https://orcid.org/0000-0002-0070-6607)
- Katja Höschler (ORCID: https://orcid.org/0000-0003-4837-0433)
- Conall H. Watson (ORCID: https://orcid.org/0000-0002-2469-791X)
- Jamie Lopez Bernal (ORCID: https://orcid.org/0000-0002-1301-5653)
- Maria Zambon (ORCID: https://orcid.org/0000-0002-8897-7881)
- Beatrix Kele (ORCID: https://orcid.org/0000-0003-1273-7299)
- Kimberly Marsh (ORCID: https://orcid.org/0000-0002-2721-1639)
- Rebecca Symes (ORCID: https://orcid.org/0009-0003-4218-6405)
Institutions
- National Security Agency (US)
- Nottingham University Hospitals NHS Trust (GB)
- University of Strathclyde (GB)
- Public Health Scotland (GB)
- University of Edinburgh (GB)
Publication Details
- Journal
- Wellcome Open Research
- Published
- 2025-12-05
- DOI
- https://doi.org/10.12688/wellcomeopenres.24371.1
- Primary Topic
- Respiratory viral infections research
- Type
- article
- Field-Weighted Citation Impact
- 0.00