Long-Term Oncological Outcomes for Locally Advanced Rectal Cancer Patients with Pathological Complete Response After Neoadjuvant Chemoradiotherapy: A Turkish Oncology Group Study
The goal of this study was to look at the long-term survival outcomes and clinical characteristics of stage II/III locally advanced rectal cancer (LARC) patients who acquired pathological complete response (pCR) following neoadjuvant chemoradiotherapy (NCRT). The clinicopathological characteristics and treatment details of 277 LARC patients with pCR, relapse-free survival (RFS), overall survival (OS), and locoregional and systemic recurrence rates, were assessed. The 5-year RFS and OS rates were 85.6% and 90.9%. The rates of local and systemic recurrence were 3.6% and 7.9%. Our study confirmed the favorable results in survival in patients with LARC who achieved pCR.
Authors
- Ahmet Bılıcı (ORCID: https://orcid.org/0000-0002-0443-6966)
- Şefika Arzu Ergen (ORCID: https://orcid.org/0000-0002-7819-2335)
- Özkan Alan (ORCID: https://orcid.org/0000-0002-6635-2012)
- Elkhan Mammadov
- Tülay Eren (ORCID: https://orcid.org/0000-0002-0088-1149)
- Atike Gökçen Demiray (ORCID: https://orcid.org/0000-0003-4397-5468)
- Pınar Gürsoy (ORCID: https://orcid.org/0000-0003-1392-6753)
- Ali Murat Tatlı (ORCID: https://orcid.org/0000-0001-9696-1102)
- Atakan Demir (ORCID: https://orcid.org/0000-0002-1940-4086)
- Didem Çolpan Öksüz (ORCID: https://orcid.org/0000-0003-4947-0428)
- Birol Ocak (ORCID: https://orcid.org/0000-0001-7537-1699)
- Rukiye Arıkan (ORCID: https://orcid.org/0000-0003-2688-1515)
- Abdilkerim Oyman (ORCID: https://orcid.org/0000-0002-2291-7544)
- Esra Sağlam (ORCID: https://orcid.org/0000-0002-4034-1614)
- Saadettin Kılıçkap (ORCID: https://orcid.org/0000-0003-1637-7390)
- Ahmet Gülmez (ORCID: https://orcid.org/0000-0002-3353-344X)
- Teoman Şakalar (ORCID: https://orcid.org/0000-0003-2749-9414)
- Bülent Karabulut (ORCID: https://orcid.org/0000-0002-1949-8334)
- Sezer Sağlam (ORCID: https://orcid.org/0000-0001-8954-5792)
- Mükremın Uysal (ORCID: https://orcid.org/0000-0002-8524-0665)
- İsmail Beypınar (ORCID: https://orcid.org/0000-0002-0853-4096)
- Hacı Mehmet Türk (ORCID: https://orcid.org/0000-0003-2206-8148)
- Gökhan Uçar (ORCID: https://orcid.org/0000-0002-7649-1075)
- Abdullah Sakin (ORCID: https://orcid.org/0000-0003-2538-8569)
- Özge Aybı (ORCID: https://orcid.org/0000-0002-5483-8584)
- Vildan Kaya (ORCID: https://orcid.org/0000-0001-9035-4977)
- Erdem Şen
- Ercan Özden (ORCID: https://orcid.org/0000-0001-6872-0723)
Institutions
- Van Yüzüncü Yıl Üniversitesi (TR)
- Aksaray University (TR)
- Bursa Uludağ Üni̇versi̇tesi̇ (TR)
- Istanbul Bilim University (TR)
- Akdeniz University (TR)
- Inonu University (TR)
- Cancer Institute (WIA) (IN)
- Bezmiâlem Vakıf Üniversitesi (TR)
- Istanbul Medipol University (TR)
- Acıbadem University (TR)
- Ege University (TR)
- Antalya Bilim University (TR)
- Ankara Numune Eğitim ve Araştırma Hastanesi (TR)
- Ümraniye Eğitim ve Araştırma Hastanesi (TR)
- Istanbul University-Cerrahpaşa (TR)
- Hacettepe University Hospital (TR)
- Sağlık Bilimleri Üniversitesi (TR)
- Dışkapı Yıldırım Beyazıt Eğitim ve Araştırma Hastanesi (TR)
- Antalya IVF (TR)
- Afyonkarahisar Sağlık Bilimleri Üniversitesi
- Pamukkale University (TR)
- Kocaeli Üniversitesi (TR)
- Afyon Kocatepe University (TR)
- Burdur Mehmet Akif Ersoy Üniversitesi (TR)
- Istanbul University (TR)
- Marmara University (TR)
Publication Details
- Journal
- Cancer Investigation
- Published
- 2025-12-05
- DOI
- https://doi.org/10.1080/07357907.2025.2595536
- Primary Topic
- Colorectal Cancer Surgical Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00