Global epidemiological and genetic characteristics of carbapenem-resistant <i>Escherichia coli</i> carrying <i>bla</i> _IMP

Compared with <i>bla</i>_NDM-positive and <i>bla</i>_KPC-positive carbapenem-resistant <i>Escherichia coli</i> (CREC), <i>bla</i>_IMP-positive CRECs are often overlooked. This study emphasized IncN plasmids, which, with their strong transferability, stability, and low fitness cost, can serve as vectors for the widespread dissemination of <i>bla</i>_IMP genes. Additionally, the study elucidated the global epidemiological status, transmission features, and potential threats of <i>bla</i>_IMP-positive CRECs through a large-scale analysis of publicly available genomic data. These findings not only facilitate a better understanding of the genetic dynamics and transmission pathways of <i>bla</i>_IMP but also help develop effective regulatory measures and antibiotic stewardship programs to alleviate the increasingly severe burden of antimicrobial resistance.