A therapeutic-grade purified exosome system alleviates osteoarthritis by regulating autophagy through the BCL2–Beclin1 axis
This study demonstrates that a therapeutic-grade exosome formulation can alleviate osteoarthritis by restoring the balance between autophagy and apoptosis through modulation of the BCL2-Beclin-1 signaling axis. These findings highlight the potential of exosome-based nanotherapeutics as a novel disease-modifying treatment strategy for degenerative joint disorders.
Authors
- Christopher H. Evans (ORCID: https://orcid.org/0000-0001-5532-2347)
- Steven L. Moran (ORCID: https://orcid.org/0000-0002-3125-7621)
- Atta Behfar (ORCID: https://orcid.org/0000-0003-3775-5784)
- Ichiro Tsukamoto (ORCID: https://orcid.org/0000-0002-2054-0384)
- Gongyin Zhao (ORCID: https://orcid.org/0000-0002-2259-4511)
- Chunfeng Zhao (ORCID: https://orcid.org/0000-0002-8737-4587)
- Farbod Yousefi
Institutions
- WinnMed (US)
- Changzhou No.2 People's Hospital (CN)
Publication Details
- Journal
- Journal of Nanobiotechnology
- Published
- 2025-12-05
- DOI
- https://doi.org/10.1186/s12951-025-03807-y
- Citations
- 3
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 5.00