Altered static and dynamic effective connectivity in patients with type 2 diabetes mellitus with and without microvascular complications
Our analysis of dynamic effective connectivity reveals that T2DM patients, particularly those with microvascular complications, undergo a state-dependent reconfiguration from compensatory high connectivity to inefficient low-connectivity states. The increased time spent in these inefficient states was associated with poorer glycemic control. Thus, this work provides a novel dynamic and directional framework for understanding the neural mechanisms of cognitive dysfunction in T2DM.
Authors
- Kun Wang (ORCID: https://orcid.org/0000-0001-9851-7080)
- Jiahe Wang (ORCID: https://orcid.org/0000-0002-7224-9716)
- Die Shen
- Xuan Huang (ORCID: https://orcid.org/0000-0003-0143-4444)
- Qiu Shijun
- Zhizhong Sun
- Ziyu Diao
Institutions
- Guangzhou University of Chinese Medicine (CN)
- State Administration of Traditional Chinese Medicine of the People's Republic of China (CN)
- First Affiliated Hospital of Guangzhou University of Chinese Medicine (CN)
Publication Details
- Journal
- European journal of medical research
- Published
- 2025-12-05
- DOI
- https://doi.org/10.1186/s40001-025-03606-z
- Citations
- 1
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.43