Efficacy and Safety of Risankizumab in Psoriatic Patients With a History of Malignancy: Real‐World Evidence From a Multicentre Spanish Study
The management of psoriasis in patients with a history of malignancy is challenging. We conducted a multicentre, retrospective study in 17 Spanish centres including 69 patients with moderate-to-severe psoriasis and a previous or current malignancy treated with risankizumab; 94.2% of patients showed no recurrence or progression of cancer, while 5.8% experienced progression during therapy. Risankizumab was associated with substantial improvement in psoriasis, with a mean final PASI score of 0.9 ± 1.7 after a mean exposure time of 72 weeks. Tolerance was favourable, and no tumour recurrence was considered treatment-related. These findings support risankizumab as an effective and safe therapeutic option for this subpopulation.
Authors
- Laura García Fernández (ORCID: https://orcid.org/0000-0003-3740-5485)
- I. Belinchón (ORCID: https://orcid.org/0000-0002-6007-7320)
- Ricardo Ruíz‐Villaverde (ORCID: https://orcid.org/0000-0002-0381-6174)
- Sergio Santos‐Alarcón (ORCID: https://orcid.org/0000-0002-0533-1605)
- Fernando Toledo Alberola
- Adrián Ballano Ruiz (ORCID: https://orcid.org/0000-0001-6256-183X)
- E. Vilarrasa Rull
- María Castellanos‐González (ORCID: https://orcid.org/0000-0001-6742-1019)
- Francisco Javier Melgosa Ramos (ORCID: https://orcid.org/0000-0003-2121-6727)
- Marta Ferrán Farrés
- Ofelia Baniandrés (ORCID: https://orcid.org/0000-0001-8183-3941)
- Jorge Magdaleno‐Tapial (ORCID: https://orcid.org/0000-0003-0046-6962)
- Luca Schneller‐Pavelescu (ORCID: https://orcid.org/0000-0001-7338-2300)
- Javier Mataix Díaz (ORCID: https://orcid.org/0000-0001-5749-1160)
- María Asunción Ballester Martínez
- Almudena Mateu Puchades
- Susana Medina Montalvo
Institutions
- Hospital de Sant Pau (ES)
- Hospital General Universitario Gregorio Marañón (ES)
- Hospital Universitari Sant Joan D'Alacant (ES)
- Hospital Universitario Príncipe de Asturias (ES)
- Instituto de Investigación Biosanitaria de Granada (ES)
- Hospital General Universitario de Elche (ES)
- Hospital Universitario Doctor Peset (ES)
- Hospital Universitario del Sureste (ES)
- Hospital General Universitario De Valencia (ES)
- Hospital Del Mar (ES)
- Hospital General Universitario de Alicante Doctor Balmis (ES)
- Hospital Vega Baja (ES)
- Hospital Universitario Lluís Alcanyís (ES)
- Hospital Universitario del Henares (ES)
- Hospital Marina Baixa (ES)
- Hospital Virgen de los Lirios (ES)
- Hospital Universitario Ramón y Cajal (ES)
Publication Details
- Journal
- Australasian Journal of Dermatology
- Published
- 2025-12-05
- DOI
- https://doi.org/10.1111/ajd.70012
- Primary Topic
- Psoriasis: Treatment and Pathogenesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00