The Importance of Early Mycological Clearance of Uncomplicated Candidaemia and Its Implications for Clinical Practice
Invasive candidiasis is a life-threatening infection associated with high morbidity, mortality and healthcare costs in both general and critical care settings. Timely diagnosis and adequate antifungal treatment are essential to improving patient outcomes and limiting unnecessary use of healthcare resources. This review explores the relationship between early Candida clearance with antifungal therapy, clinical outcomes, resistance patterns and economic impact. It also evaluates the role of diagnostic markers in facilitating early and accurate identification of candidaemia, enabling more precise and effective clinical management. Special attention is given to the challenges of managing candidaemia in critically ill and neutropenic patients, highlighting the need for tailored and timely interventions in these vulnerable populations.
Authors
- P. Lewis White (ORCID: https://orcid.org/0000-0003-3056-4205)
- Ignacio Martín‐Loeches (ORCID: https://orcid.org/0000-0002-5834-4063)
- Matteo Bassetti (ORCID: https://orcid.org/0000-0002-0145-9740)
- Martin Hoenigl (ORCID: https://orcid.org/0000-0002-1653-2824)
- Oliver A. Cornely (ORCID: https://orcid.org/0000-0001-9599-3137)
- Carolina García‐Vidal (ORCID: https://orcid.org/0000-0002-8915-0683)
- Johan A. Maertens (ORCID: https://orcid.org/0000-0003-4257-5980)
- Jean-Paul Mira (ORCID: https://orcid.org/0009-0009-5546-3292)
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- University of Cologne (DE)
- Medical University of Graz (AT)
- Université Paris Cité (FR)
- Trinity College Dublin (IE)
- University Hospital of Wales (GB)
- Public Health Wales (GB)
- Düsseldorf University Hospital (DE)
- Hôpital Cochin (FR)
- Integrated Oncology (United States) (US)
- Departament de Salut (ES)
- Hospital Clínic de Barcelona (ES)
- German Center for Infection Research (DE)
- BioTechMed-Graz (AT)
- Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (DE)
- Institut Cochin (FR)
- Ospedale Policlinico San Martino (IT)
- University Hospital Cologne (DE)
- St. James's Hospital (IE)
- Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
- Institute of Infection and Immunity (CA)
- Heinrich Heine University Düsseldorf (DE)
- Universitat de Barcelona (ES)
- University of Genoa (IT)
- KU Leuven (BE)
Publication Details
- Journal
- Mycoses
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1111/myc.70135
- Primary Topic
- Antifungal resistance and susceptibility
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Pfizer
- Sanofi
- Gilead Sciences
- Medpace
- Deutsches Zentrum für Infektionsforschung
- Cidara Therapeutics
- Asahi Kasei Pharma Corporation
- Deutsche Forschungsgemeinschaft
- Bundesministerium für Bildung und Forschung
- Novo Nordisk
- Astellas Pharma
- Shionogi
- Servier
- Daiichi Sankyo Europe