Iridium-Catalyzed Enantioselective C( <i>sp</i> <sup>3</sup> )–H Borylation of Bicyclo[1.1.0]butanes
Bicyclo[1.1.0]butanes (BCBs) have attracted considerable interest in organic synthesis due to their versatile reactivity. However, the asymmetric synthesis of these strained systems remains a formidable challenge. We herein report an iridium-catalyzed enantioselective C(<i>sp</i><sup>3</sup>)-H borylation of BCBs, providing access to a range of optically active borylated BCBs with high enantioselectivities. We also demonstrated synthetic applications by downstream transformations, particularly in the stereoselective preparation of optically active multisubstituted cyclobutenes.
Authors
- Senmiao Xu (ORCID: https://orcid.org/0000-0003-0249-8765)
- Tianqi Jia (ORCID: https://orcid.org/0000-0001-9797-6904)
- Lili Chen (ORCID: https://orcid.org/0000-0003-0026-4877)
- Wei Sun (ORCID: https://orcid.org/0000-0003-4448-2390)
Institutions
- Hangzhou Normal University (CN)
- Chinese Academy of Sciences (CN)
- Lanzhou Institute of Chemical Physics (CN)
- Green Chemistry (PL)
- State Key Laboratory of Chemical Engineering (CN)
- University of Chinese Academy of Sciences (CN)
- East China Normal University (CN)
Publication Details
- Journal
- Journal of the American Chemical Society
- Published
- 2025-12-05
- DOI
- https://doi.org/10.1021/jacs.5c16702
- Citations
- 1
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.94