Co-MHAT-Catalyzed Wacker-Type Oxidation of 1,3-Enynes into Ynones

The transformation of 1,3-enynes is one of the important methods for obtaining a variety of valuable organic molecules. In the past few decades, significant progress has been made in the difunctionalization of 1,3-enynes via a radical process. However, the hydrofunctionalization of 1,3-enynes has been studied less. Herein, we describe the first example of reductive Co-MHAT-catalyzed Wacker-type oxidation of 1,3-enynes under air conditions with Markovnikov regioselectivity. Valuable conjugated ynones were obtained from the readily available starting material. Furthermore, a broad substrate scope with good functional group compatibility, simple operation, mild conditions, diverse downstream transformations, and excellent late-stage modifications demonstrated this method has significant advantages in practical utility.