The association of polypharmacy with intrinsic capacity: an analysis of the WHO ICOPE pilot data from Lianyungang, China
An increase in the number of medications used by older adults may be positively associated with a decline in intrinsic capacity (IC). The prevalence of IC decline is significantly higher among individuals taking ≥5 medications compared to those using fewer medications. These findings suggest that polypharmacy is associated with IC decline and could serve as a potential indicator for IC decline. Prospective studies are needed to validate the causal relationship.
Authors
- Yan Dong (ORCID: https://orcid.org/0000-0001-6171-1891)
- Yuan Zhang (ORCID: https://orcid.org/0000-0002-6879-7859)
- Jing Wang (ORCID: https://orcid.org/0000-0001-9491-4994)
- Jun Xia (ORCID: https://orcid.org/0000-0002-1123-2662)
- A. Guo (ORCID: https://orcid.org/0009-0008-9190-9426)
- Qiong Jiang (ORCID: https://orcid.org/0000-0002-5962-8180)
- Zhihui Gu (ORCID: https://orcid.org/0000-0003-4456-9197)
- Yun Xia (ORCID: https://orcid.org/0000-0003-2437-5467)
- Qian Sun (ORCID: https://orcid.org/0000-0002-0774-1608)
Institutions
- Lianyungang Oriental Hospital (CN)
- Second Hospital of Shandong University (CN)
- The First People’s Hospital of Lianyungang (CN)
- Community Health Center (US)
- First Hospital of Lanzhou University (CN)
- Anyang Hospital of Traditional Chinese Medicine (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2025-12-05
- DOI
- https://doi.org/10.3389/fmed.2025.1673885
- Primary Topic
- Pharmaceutical Practices and Patient Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00