Longitudinal clinical trial enrollment trends across 341 US FDA-approved drugs and their guiding role in precision medicine strategies

Persistent imbalances in trial enrollment limit the delivery of precision medicine. Trial location and regulatory designations influence who is included. Earlier planning of trials and more strategic site selection improve the potential for future treatments to serve individuals from all racial and ethnic groups.

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Publication Details

Journal
Communications Medicine
Published
2025-12-05
DOI
https://doi.org/10.1038/s43856-025-01270-2
Primary Topic
Statistical Methods in Clinical Trials
Type
article
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article

Longitudinal clinical trial enrollment trends across 341 US FDA-approved drugs and their guiding role in precision medicine strategies

Sophie Zaaijer, Simon C. Groen
Communications Medicine
Statistical Methods in Clinical Trials
article

Longitudinal clinical trial enrollment trends across 341 US FDA-approved drugs and their guiding role in precision medicine strategies

Sophie Zaaijer, Simon C. Groen
article en

Abstract

Persistent imbalances in trial enrollment limit the delivery of precision medicine. Trial location and regulatory designations influence who is included. Earlier planning of trials and more strategic site selection improve the potential for future treatments to serve individuals from all racial and ethnic groups.

Communications MedicineVol. 5(1)
University of California, Riverside (US), University of California, Irvine (US), Cornell University (US)
Openalex Percentile: Top 65%
Statistical Methods in Clinical Trials
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Longitudinal clinical trial enrollment trends across 341 US FDA-approved drugs and their guiding role in precision medicine strategies — Sophie Zaaijer, Simon C. Groen · Communications Medicine (2025) | TGRS Research Map | TGRS