Synthesis and preclinical evaluation of FAP-targeting radiotracers for PET and optical imaging
Two FAP-targeting bimodal ligands were synthesized and evaluated in vitro and in vivo, showing high specificity and selectivity, along with rapid and selective tumor accumulation. Their long tumor retention and high imaging contrast make them promising candidates for clinical translation.
Authors
- Sven Stadlbauer (ORCID: https://orcid.org/0000-0003-2276-5330)
- Klaus Kopka (ORCID: https://orcid.org/0000-0003-4846-1271)
- Cornelius K. Donat (ORCID: https://orcid.org/0000-0003-3750-3579)
- Jürgen Kogler (ORCID: https://orcid.org/0009-0005-4996-7399)
- Johanna Trommer
Institutions
- German Cancer Research Center (DE)
- Heidelberg University (DE)
- Helmholtz-Zentrum Dresden-Rossendorf (DE)
- University Hospital Carl Gustav Carus (DE)
- Hochschule für Technik und Wirtschaft Dresden – University of Applied Sciences (DE)
- Technische Universität Dresden (DE)
Publication Details
- Journal
- EJNMMI Radiopharmacy and Chemistry
- Published
- 2025-12-05
- DOI
- https://doi.org/10.1186/s41181-025-00398-9
- Citations
- 1
- Primary Topic
- Peptidase Inhibition and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 1.05