Large-scale plasma proteomics reveals bidirectional associations between sleep patterns and inflammatory bowel disease: a prospective cohort study
Unhealthy sleep and IBD are bidirectionally linked, with inflammatory and metabolic processes mediating this association. These findings highlight potential biomarkers and therapeutic targets, underscoring the importance of integrating sleep assessments into IBD management strategies.
Authors
- Jie Hu (ORCID: https://orcid.org/0000-0002-6137-9064)
- Kaixing Le
- Jinghao Sheng (ORCID: https://orcid.org/0000-0002-1207-7449)
- Nick Powell (ORCID: https://orcid.org/0000-0003-3231-6950)
- Rongpan Bai (ORCID: https://orcid.org/0000-0002-0687-2729)
- Jinpiao Zhu
- Zhigang Liu (ORCID: https://orcid.org/0000-0002-1363-6708)
- Daqing Ma (ORCID: https://orcid.org/0000-0003-1235-0537)
- Yang Bi (ORCID: https://orcid.org/0000-0001-7263-1002)
- Yaru Liu
Institutions
- Sir Run Run Shaw Hospital (CN)
- Children's Hospital of Zhejiang University (CN)
- Luoyang Central Hospital Affiliated to Zhengzhou University (CN)
- Chelsea and Westminster Hospital (GB)
- Imperial College London (GB)
- Zhejiang University (CN)
Publication Details
- Journal
- BMC Medicine
- Published
- 2025-12-05
- DOI
- https://doi.org/10.1186/s12916-025-04539-4
- Primary Topic
- Sleep and related disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00