CD33 drives cutaneous melanoma: Mendelian randomization confirms causality; multi-omics and in vitro experiments reveal M2 macrophage polarization-mediated progression
By integrating MR, multi-omics transcriptome analysis and in vitro experiments validation, the present study revealed that CD33 could facilitate CM development by promoting M2 macrophages polarization.
Authors
- Longyuan Hu
- Limin Liu (ORCID: https://orcid.org/0000-0003-2527-7201)
- Yapeng Wang (ORCID: https://orcid.org/0000-0002-2923-1406)
- Xianling Liu (ORCID: https://orcid.org/0000-0003-2653-6586)
Institutions
- Central South University (CN)
- Guilin Medical University (CN)
- Equilibrium Research (GB)
- Fourth Affiliated Hospital of Guangxi Medical University (CN)
- Second Xiangya Hospital of Central South University (CN)
Publication Details
- Journal
- International Journal of Surgery
- Published
- 2025-12-02
- DOI
- https://doi.org/10.1097/js9.0000000000004100
- Citations
- 1
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.80