Glioblastoma-associated fibroblasts enhance vascular stiffness and confer to poor prognosis
Our study defines COL6A3+ GAFs as a key feature of GBM, driving vascular dysfunction and hypoxi, and suggests COL6A3 as a promising therapeutic target for disrupting fibrosis-angiogenesis crosstalk in GBM.
Authors
- S.-Y. Wang
- Xiaoling She
- Xinmiao Long (ORCID: https://orcid.org/0000-0003-2898-0947)
- Wei‐Cheng Huang (ORCID: https://orcid.org/0000-0003-4437-3530)
- Minghua Wu (ORCID: https://orcid.org/0000-0001-5547-907X)
- Kun Deng
- Xiangyu Wang (ORCID: https://orcid.org/0000-0001-5397-1909)
- Wei Gao (ORCID: https://orcid.org/0000-0003-1026-3878)
- Fan Guan
- Shu Cui
- Xuetong Li (ORCID: https://orcid.org/0000-0003-0029-2296)
- Qing Liu (ORCID: https://orcid.org/0000-0001-8374-9882)
- Shuai Chen (ORCID: https://orcid.org/0000-0002-8293-7491)
- Meng Huang (ORCID: https://orcid.org/0000-0003-2575-9403)
- Yinfei Du (ORCID: https://orcid.org/0000-0003-4567-655X)
- Xiang Lin
Institutions
- Central South University (CN)
- Ministry of Health (UG)
- Hunan Cancer Hospital (CN)
- Second Xiangya Hospital of Central South University (CN)
- Xiangya Hospital Central South University (CN)
Publication Details
- Journal
- International Journal of Surgery
- Published
- 2025-12-02
- DOI
- https://doi.org/10.1097/js9.0000000000004114
- Primary Topic
- Angiogenesis and VEGF in Cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00