ANKRD46 as a shared diagnostic and therapeutic marker in keloid and type 2 diabetes mellitus identified via multi-omics and experimental validation
ANKRD46 is a promising shared diagnostic and therapeutic target for keloids and T2DM, with its role in regulating immune responses and fibrosis supported by both computational and experimental data. This study highlights the potential of ANKRD46 in modulating the IL6-JAK-STAT3 pathway, providing a foundation for future therapeutic strategies targeting both diseases.
Authors
- Pu Zhao (ORCID: https://orcid.org/0000-0001-6164-8300)
- Jie Ren (ORCID: https://orcid.org/0000-0001-8831-5899)
- Yiyi Gong
- Shunming Xu (ORCID: https://orcid.org/0000-0002-3304-2261)
- Tingting Yu (ORCID: https://orcid.org/0000-0003-1694-7592)
- Ningwen Zhu (ORCID: https://orcid.org/0000-0003-4224-4188)
- Yanyun Cao (ORCID: https://orcid.org/0009-0004-9884-702X)
- Fang Liu (ORCID: https://orcid.org/0000-0002-5379-8816)
Institutions
- Fudan University (CN)
- Ningxia Medical University (CN)
- Huashan Hospital (CN)
- Pudong New Area People's Hospital (CN)
Publication Details
- Journal
- International Journal of Surgery
- Published
- 2025-12-02
- DOI
- https://doi.org/10.1097/js9.0000000000004116
- Citations
- 1
- Primary Topic
- Dermatologic Treatments and Research
- Type
- article
- Field-Weighted Citation Impact
- 2.00