LARP7 protects against ischemic brain injury by modulating NLRP3 deacetylation to suppress neuronal pyroptosis
LARP7 enhances Sirt1 deacetylase activity to regulate NLRP3 deacetylation, thereby inhibiting inflammasome assembly and neuronal pyroptosis after ischemic stroke. Targeting LARP7 could represent a promising therapeutic strategy for ischemic stroke.
Authors
- Jun Wen (ORCID: https://orcid.org/0000-0002-2678-7329)
- Hao Tang (ORCID: https://orcid.org/0000-0002-6973-8121)
- Wenjie Zi (ORCID: https://orcid.org/0000-0001-6323-2659)
- Qinghuan Yang
- Ting Qin (ORCID: https://orcid.org/0000-0002-2528-7103)
- Qin Yang (ORCID: https://orcid.org/0000-0003-4040-1661)
- Yu Ren (ORCID: https://orcid.org/0000-0003-3123-9949)
- Jiagui Huang
- Youlin Wu
- Ling Wang (ORCID: https://orcid.org/0009-0005-4954-4409)
- Yan He (ORCID: https://orcid.org/0009-0008-1631-6583)
- Changqing Li (ORCID: https://orcid.org/0000-0003-2994-4315)
- Jiani Li (ORCID: https://orcid.org/0000-0003-3939-2542)
- Yong Zhao (ORCID: https://orcid.org/0000-0001-9732-8624)
Institutions
- Army Medical University (CN)
- Dalian Medical University (CN)
- Mianyang Third People's Hospital (CN)
- Second Affiliated Hospital of Chongqing Medical University (CN)
- Xinqiao Hospital (CN)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Second People’s Hospital of Yibin (CN)
- First People's Hospital of Chongqing (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Journal of Neuroinflammation
- Published
- 2025-12-05
- DOI
- https://doi.org/10.1186/s12974-025-03649-3
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00