Complement pathway dysregulation and astrocyte alterations in Down syndrome: evidence from postmortem brain tissue and iPSC-derived astrocytes
These findings highlight the potential contribution of astrocyte-driven complement signaling to DS neuropathogenesis. While further validation is needed, this work points to a candidate pathway that may serve as a target for future therapeutic investigation to improve the quality of life for individuals with DS.
Authors
- Helder I. Nakaya (ORCID: https://orcid.org/0000-0001-5297-9108)
- Bruna Lancia Zampieri (ORCID: https://orcid.org/0000-0003-0091-1894)
- Bruno Yukio Yokota-Moreno (ORCID: https://orcid.org/0000-0001-5741-9847)
- André Luíz Teles e Silva (ORCID: https://orcid.org/0000-0003-4621-7742)
- Andréa L. Sertié (ORCID: https://orcid.org/0000-0002-7453-0560)
- Jesús Ávila (ORCID: https://orcid.org/0000-0002-6288-0571)
- Paula Regina de Oliveira (ORCID: https://orcid.org/0009-0004-1258-4733)
- Jéssica da Silva Fausto
Institutions
- Universidade de São Paulo (BR)
- Hospital Israelita Albert Einstein (BR)
Publication Details
- Journal
- Acta Neuropathologica Communications
- Published
- 2025-12-05
- DOI
- https://doi.org/10.1186/s40478-025-02090-0
- Primary Topic
- Down syndrome and intellectual disability research
- Type
- article
- Field-Weighted Citation Impact
- 0.00