Mechanistic insights into PPARγ's role in suppressing collagen-driven platelet activation
These findings identify PPARγ as a regulator of early platelet activation by targeting both Lyn- and Fyn-dependent proximal GPVI signaling and highlight PPARγ ligands as potential dual-purpose therapeutics with antithrombotic benefits alongside their metabolic actions.
Authors
- Solee Kim
- Taeryeong Kim
- Joohyuk Sohn (ORCID: https://orcid.org/0000-0002-2303-2764)
- Su Bin Wang
- Tong‐Shin Chang (ORCID: https://orcid.org/0000-0003-4472-5436)
- Eun Bee Oh
Institutions
- Ewha Womans University (KR)
- Seoul National University (KR)
- New Generation University College (ET)
- National University College (PR)
Publication Details
- Journal
- Life Sciences
- Published
- 2025-12-05
- DOI
- https://doi.org/10.1016/j.lfs.2025.124138
- Citations
- 1
- Primary Topic
- Platelet Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.77