High sensitivity of biliary brush cytology in patients with suspected perihilar or intrahepatic cholangiocarcinoma: a prospective cohort comparison with historical controls
A modification in the processing of cytopathology led to a significant improvement in the sensitivity of the first bile duct brush to 78 %. Furthermore, adding NGS increased sensitivity to 83 %, an extra brush sample to 85 %, and intraductal biopsies to 88 %.
Authors
- Roy L.J. van Wanrooij (ORCID: https://orcid.org/0000-0003-0477-4532)
- Rogier P. Voermans (ORCID: https://orcid.org/0000-0002-9969-019X)
- Anne M. Uyterlinde
- Frederike Dijk (ORCID: https://orcid.org/0000-0003-3970-6601)
- Jeska A. Fritzsche (ORCID: https://orcid.org/0000-0003-3680-5006)
- IJsbrand A.J. Zijlstra (ORCID: https://orcid.org/0000-0002-2089-1918)
- Joanne Verheij (ORCID: https://orcid.org/0000-0003-1283-630X)
- Otto M. van Delden (ORCID: https://orcid.org/0000-0003-3342-9367)
- Joris I. Erdmann (ORCID: https://orcid.org/0000-0001-8233-1505)
- Cyriel Y. Ponsioen (ORCID: https://orcid.org/0000-0001-5203-0453)
- Heinz‐Josef Klümpen (ORCID: https://orcid.org/0000-0002-7290-1823)
- Arantza Fariña Sarasqueta (ORCID: https://orcid.org/0000-0002-4307-1568)
- Mattheus C.B. Wielenga (ORCID: https://orcid.org/0000-0002-5737-8018)
- Geert Kazemier (ORCID: https://orcid.org/0000-0002-9811-3497)
- Paul Fockens (ORCID: https://orcid.org/0000-0002-2382-0672)
- Esmée Smit (ORCID: https://orcid.org/0009-0002-3333-6830)
Institutions
- Amsterdam Neuroscience (NL)
- Amsterdam University Medical Centers (NL)
- Vrije Universiteit Amsterdam (NL)
- University of Amsterdam (NL)
Publication Details
- Journal
- HPB
- Published
- 2025-12-05
- DOI
- https://doi.org/10.1016/j.hpb.2025.12.012
- Primary Topic
- Gallbladder and Bile Duct Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Gilead Sciences
- Boston Scientific Corporation
- Cook Medical
- Mylan
- ZonMw
- Ipsen
- Cancer Center Amsterdam