Biomarkers of mitochondrial permeability transition-driven necrosis in the regulation of ulcerative colitis
The MPTDN-related genes CASP1 and CASP4 have been identified as potential biomarkers for the diagnosis of UC and are associated with abnormal immune cell infiltration in UC patients. Additionally, CASP1 may serve as a predictor of sensitivity to infliximab therapy.
Authors
- Yong Yao (ORCID: https://orcid.org/0000-0001-5566-4822)
- Fengjun Ni (ORCID: https://orcid.org/0009-0006-0143-8794)
- Hua-Yuan Yang (ORCID: https://orcid.org/0000-0002-5553-6705)
- Mingzhe Sun (ORCID: https://orcid.org/0000-0002-1860-4414)
Institutions
- Shanghai University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- PeerJ
- Published
- 2025-12-05
- DOI
- https://doi.org/10.7717/peerj.20345
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00