Evaluating methodological constraints in PET imaging of neuropeptide Y2 receptors with N-[11C]-methyl-(R)-JNJ-31020028 in brains of C57BL/6J mice
N-[<sup>11</sup>C]methyl-(R)-JNJ-31020028 binds selectively to NPY2R but undergoes rapid metabolism and strong P-gp-mediated efflux at the murine blood-brain barrier. Reliable data interpretation requires early imaging and metabolite correction. For preclinical NPY2R-PET, pharmacological P-gp inhibition may be essential, and future tracers should be optimized for improved metabolic stability.
Authors
- Thomas Wanek (ORCID: https://orcid.org/0000-0002-0404-4452)
- Oliver Langer (ORCID: https://orcid.org/0000-0002-4048-5781)
- Karsten Bamminger (ORCID: https://orcid.org/0000-0003-3811-7485)
- Marcus Hacker (ORCID: https://orcid.org/0000-0002-4222-4083)
- Berit Østergaard Christoffersen
- Lena Zachhuber
- Claudia Kuntner (ORCID: https://orcid.org/0000-0002-5988-1434)
- Eduardo Felipe Alves Fernandes (ORCID: https://orcid.org/0000-0003-3406-1357)
- Severin Mairinger (ORCID: https://orcid.org/0000-0001-5094-9351)
- Ines Lopez-Martinez (ORCID: https://orcid.org/0009-0006-9057-6047)
Institutions
- Novo Nordisk (Denmark) (DK)
- Medical University of Vienna (AT)
Publication Details
- Journal
- EJNMMI Radiopharmacy and Chemistry
- Published
- 2025-12-05
- DOI
- https://doi.org/10.1186/s41181-025-00407-x
- Primary Topic
- Neuropeptides and Animal Physiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00