Correlation of <i>PD‐L1</i> Expression With Microsatellite Instability and p53 Status in Endometrial Cancer: A Clinicopathological and Molecular Analysis

No molecular marker demonstrated a significant association with recurrence risk (p > 0.05), in contrast to the FIGO stage, which showed a significant correlation (p < 0.001). Although PD-L1 expression was rare, it was significantly associated with microsatellite instability, highlighting the potential of molecular classification to identify candidates for immunotherapy. However, the low frequency of PD-L1 positivity and the small sample size warrant caution in interpreting these findings, and further research is needed to confirm the clinical relevance of PD-L1 in endometrial cancer.

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Publication Details

Journal
Journal of obstetrics and gynaecology research
Published
2025-12-01
DOI
https://doi.org/10.1111/jog.70162
Primary Topic
Endometrial and Cervical Cancer Treatments
Type
article
Field-Weighted Citation Impact
0.00
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article

Correlation of PD‐L1 Expression With Microsatellite Instability and p53 Status in Endometrial Cancer: A Clinicopathological and Molecular Analysis

Janusz Kopczyński, Anita Chudecka-Głaz, Andrzej Wróbel, Tomasz Kluz et al.
Journal of obstetrics and gynaecology research
Endometrial and Cervical Cancer Treatments
article

Correlation of PD‐L1 Expression With Microsatellite Instability and p53 Status in Endometrial Cancer: A Clinicopathological and Molecular Analysis

Janusz Kopczyński, Anita Chudecka-Głaz, Andrzej Wróbel, Tomasz Kluz, M Misiek, Aleksandra Misiek
article en

Abstract

No molecular marker demonstrated a significant association with recurrence risk (p > 0.05), in contrast to the FIGO stage, which showed a significant correlation (p < 0.001). Although PD-L1 expression was rare, it was significantly associated with microsatellite instability, highlighting the potential of molecular classification to identify candidates for immunotherapy. However, the low frequency of PD-L1 positivity and the small sample size warrant caution in interpreting these findings, and further research is needed to confirm the clinical relevance of PD-L1 in endometrial cancer.

Journal of obstetrics and gynaecology researchVol. 51(12)
Medical University of Lublin (PL), Jan Kochanowski University (PL), Holy Cross University (PL), Pomeranian Medical University (PL), University of Rzeszów (PL)
Openalex Percentile: Top 51%
Endometrial and Cervical Cancer Treatments
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