Correlation of <i>PD‐L1</i> Expression With Microsatellite Instability and p53 Status in Endometrial Cancer: A Clinicopathological and Molecular Analysis
No molecular marker demonstrated a significant association with recurrence risk (p > 0.05), in contrast to the FIGO stage, which showed a significant correlation (p < 0.001). Although PD-L1 expression was rare, it was significantly associated with microsatellite instability, highlighting the potential of molecular classification to identify candidates for immunotherapy. However, the low frequency of PD-L1 positivity and the small sample size warrant caution in interpreting these findings, and further research is needed to confirm the clinical relevance of PD-L1 in endometrial cancer.
Authors
- Janusz Kopczyński
- Anita Chudecka-Głaz (ORCID: https://orcid.org/0000-0003-2784-7968)
- Andrzej Wróbel (ORCID: https://orcid.org/0000-0002-5772-0573)
- Tomasz Kluz (ORCID: https://orcid.org/0000-0002-4798-3986)
- M Misiek (ORCID: https://orcid.org/0009-0006-5414-6234)
- Aleksandra Misiek
Institutions
- Medical University of Lublin (PL)
- Jan Kochanowski University (PL)
- Holy Cross University (PL)
- Pomeranian Medical University (PL)
- University of Rzeszów (PL)
Publication Details
- Journal
- Journal of obstetrics and gynaecology research
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1111/jog.70162
- Primary Topic
- Endometrial and Cervical Cancer Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00