Skeletal muscle adiposity and cognitive decline in a biracial cohort: Insights from coronary artery risk development in young adults (CARDIA) study
Greater myosteatosis predicted slower cognitive processing speed in 5 years. Greater myosteatosis in Whites, but not Blacks, resulted in cognitive decline. Myosteatosis predicted cognitive decline beyond traditional dementia risk factors. Ethnicity might modify links between myosteatosis and cognitive decline. Abdominal CT scans may help identify middle-aged adults at risk for dementia. There is a critical need for more longitudinal studies.
Authors
- J. Jeffrey Carr (ORCID: https://orcid.org/0000-0002-4398-8237)
- Adrianna I Acevedo-Fontánez (ORCID: https://orcid.org/0000-0003-0107-5170)
- Sangeeta Nair (ORCID: https://orcid.org/0000-0002-9725-9195)
- Ryan Cvejkus (ORCID: https://orcid.org/0000-0001-5287-5341)
- James Greg Terry (ORCID: https://orcid.org/0000-0001-6659-3441)
- Kristine S. Yaffe (ORCID: https://orcid.org/0000-0003-0919-3825)
- Emma Barinas‐Mitchell (ORCID: https://orcid.org/0000-0002-7280-7781)
- Iva Miljkovic (ORCID: https://orcid.org/0000-0002-3155-9777)
- Caterina Rosano (ORCID: https://orcid.org/0000-0002-0909-1506)
Institutions
- University of Pittsburgh (US)
- University of California, San Francisco (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz.70846
- Primary Topic
- Nutrition and Health in Aging
- Type
- article
- Field-Weighted Citation Impact
- 0.00