From Mind to Liver: Exploring the Causal Relationship Between Anxiety Disorders and Non-Alcoholic Fatty Liver Disease Through Mendelian Randomization and UK Biobank Validation
Our study provides converging evidence from genetic and observational data suggesting that anxiety disorders may be associated with an increased risk of NAFLD onset. This relationship necessitates a reconsideration of both NAFLD management and pharmacotherapy for anxiety disorders, advocating for a shift from a specialized clinical focus to a comprehensive community-level strategy for addressing non-communicable diseases (NCDs).
Authors
- Guotao Lu
- Qinghui Niu (ORCID: https://orcid.org/0009-0005-8158-7484)
- Xiangjia Zhu (ORCID: https://orcid.org/0000-0001-6131-9582)
- Xin Liu (ORCID: https://orcid.org/0000-0003-0832-327X)
- Chang Li (ORCID: https://orcid.org/0000-0001-9918-6906)
- Yu Qian (ORCID: https://orcid.org/0000-0001-6754-5871)
- Xiaowu Dong (ORCID: https://orcid.org/0000-0002-5717-5384)
- Hong Zhao
- Hui Song (ORCID: https://orcid.org/0009-0006-8820-3057)
Institutions
- Qingdao University (CN)
- Chinese University of Hong Kong (HK)
- Eye & ENT Hospital of Fudan University (CN)
- Affiliated Hospital of Qingdao University (CN)
- Qingdao Municipal Hospital (CN)
- Zigong First People's Hospital (CN)
- Qingdao Eighth People's Hospital (CN)
- Yangzhou University (CN)
Publication Details
- Journal
- Journal of Multidisciplinary Healthcare
- Published
- 2025-12-01
- DOI
- https://doi.org/10.2147/jmdh.s546590
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China