Calcifying fibrous tumours of the diaphragm: A case report and literature review

Calcifying fibrous tumour (CFT), also known as calcifying fibrous pseudotumor, is a rare benign tumour that accounts for ~0.5% of all diaphragmatic tumours. It affects predominantly children and young adults, with a slight female predilection. Owing to its non-specific clinical presentations and imaging features along with its indolent growth pattern, CFT is frequently misdiagnosed. Histopathological examination remains the diagnostic gold standard, while complete surgical excision constitutes the mainstay of treatment. The present study reported a rare case of diaphragmatic CFT. Furthermore, all the case reports of CFT published in English in the PubMed database from 1946 to 2024 and detailed its diagnostic workup and therapeutic management were reviewed to enhance the recognition of CFT. The present study aims to reduce the number of missed diagnoses and misdiagnoses of CFT and the number of unnecessary high-risk surgeries, thereby improving the quality of life of patients with CFT.

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Publication Details

Journal
Experimental and Therapeutic Medicine
Published
2025-12-05
DOI
https://doi.org/10.3892/etm.2025.13042
Primary Topic
IgG4-Related and Inflammatory Diseases
Type
article
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article

Calcifying fibrous tumours of the diaphragm: A case report and literature review

Lingling Yuan, Gang Cheng, Meifang Wang, Jialong Guo et al.
Experimental and Therapeutic Medicine
IgG4-Related and Inflammatory Diseases
article

Calcifying fibrous tumours of the diaphragm: A case report and literature review

Lingling Yuan, Gang Cheng, Meifang Wang, Jialong Guo, Hansheng Wang, Sijia Guo, Wenya Han, Yurong Tuo, Chuanyong Xiao
article en

Abstract

Calcifying fibrous tumour (CFT), also known as calcifying fibrous pseudotumor, is a rare benign tumour that accounts for ~0.5% of all diaphragmatic tumours. It affects predominantly children and young adults, with a slight female predilection. Owing to its non-specific clinical presentations and imaging features along with its indolent growth pattern, CFT is frequently misdiagnosed. Histopathological examination remains the diagnostic gold standard, while complete surgical excision constitutes the mainstay of treatment. The present study reported a rare case of diaphragmatic CFT. Furthermore, all the case reports of CFT published in English in the PubMed database from 1946 to 2024 and detailed its diagnostic workup and therapeutic management were reviewed to enhance the recognition of CFT. The present study aims to reduce the number of missed diagnoses and misdiagnoses of CFT and the number of unnecessary high-risk surgeries, thereby improving the quality of life of patients with CFT.

Experimental and Therapeutic MedicineVol. 31(2)
Hubei University of Medicine (CN), Taihe Hospital (CN)
Openalex Percentile: Top 45%
IgG4-Related and Inflammatory Diseases
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Calcifying fibrous tumours of the diaphragm: A case report and literature review — Lingling Yuan, Gang Cheng, et al. · Experimental and Therapeutic Medicine (2025) | TGRS Research Map | TGRS