Risk factors of serofast state in patients undergoing syphilis: a meta-analysis of 17 cohort studies
Female gender, HIV coinfection, primary syphilis, latent syphilis, and low rapid plasma reagin (RPR) titers (≤1:32) emerged as significant risk factors for serofast state development, requiring particular attention during therapeutic management to optimize syphilis treatment outcomes.
Authors
- Yuan Ouyang (ORCID: https://orcid.org/0000-0003-2093-8795)
- Lin Jin (ORCID: https://orcid.org/0000-0001-6273-9140)
- Chunlan Xiao
- Xin Zeng (ORCID: https://orcid.org/0000-0001-9649-1323)
- Yanan Niu (ORCID: https://orcid.org/0000-0002-6874-7069)
- Lizi Liao (ORCID: https://orcid.org/0000-0002-9973-3305)
- Haoyun Wang (ORCID: https://orcid.org/0000-0002-2972-2627)
- Peng Liu (ORCID: https://orcid.org/0000-0002-1004-2664)
- Jiaxin Chen (ORCID: https://orcid.org/0000-0002-3507-6991)
- Na Yang (ORCID: https://orcid.org/0000-0002-7414-5398)
- Chengbin Zhu
- Linna Liu (ORCID: https://orcid.org/0000-0002-2357-3237)
- Hong Huang (ORCID: https://orcid.org/0000-0003-4643-5985)
- Weidong Gong
Institutions
- Hengyang Normal University (CN)
- University of South China (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-12-05
- DOI
- https://doi.org/10.3389/fimmu.2025.1689904
- Citations
- 1
- Primary Topic
- Syphilis Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- Scientific Research Foundation of Hunan Provincial Education Department