Pro-yellow laser therapy in vascular and non-vascular skin disorders: A narrative review

The pro-yellow laser (PYL), with a wavelength of 577 nm, is an ideal tool for treating vascular lesions and vascular malformations in the skin, and is also a powerful therapeutic modality that can be applied to non-vascular conditions. By penetrating deeper than standard lasers, it simultaneously targets both prominent lesions and underlying structures. The lesion turns white immediately after exposure to the appropriate dose, serving as a clinical indicator of thermal damage. Results can be obtained more safely, permanently, and with fewer side effects for lighter and darker skin tones. Neither the dye nor the gel used in pulsed dye and Intense Pulsed Light (IPL) laser systems is required with the Pro Yellow Laser (PYL). Likewise, it does not require a heavy and oversized system, as in the copper bromide laser or a cooling apparatus, as in the IPL laser system, which makes PYL superior to these treatment modalities. We reviewed the most recent studies to evaluate the role of PYL in the treatment of vascular and non-vascular skin diseases and the evidence for efficacy or the lack of such evidence. We provided up-to-date details on the use of PYL to treat both vascular and non-vascular skin conditions, including facial telangiectasia, poikiloderma of civatte, facial erythema, keratosis pilaris rubra, port-wine stain, venous lake, spider angioma, cherry angioma, hemangioma, genital angiokeratoma, Becker’s nevus, melasma, rosacea, post-acne erythema, and vulvar syringoma, ephelides, solar lentigines, and onychomycosis.