Post-COVID-19 era pathogen profiles and influencing factors for hospital patients with lower respiratory tract infections in Shenzhen, China
Different age groups of hospitalized patients showed different pathogen profiles and types of co-infection, indicating the significance of age-targeted clinical medical practice. The most common pathogens that caused LRTIs were <i>S. aureus</i>, <i>P. aeruginosa</i>, and <i>H. influenzae</i>. Older age, multiple infections, pleural effusion, diabetes mellitus, hypertension, shortness of breath, and infection with <i>P. aeruginosa</i>, SARS-CoV-2, or HHV contribute to prolonged LOS. tNGS testing should be prioritized for immunocompromised and critically ill patients.
Authors
- Zhanhong Rao
- D. S. Huang
- Tengyingzi Liu
- Yongchao Guo (ORCID: https://orcid.org/0000-0003-4238-6696)
- Dandan Niu (ORCID: https://orcid.org/0000-0003-4627-0922)
- Yingluan Zhang (ORCID: https://orcid.org/0000-0003-1399-9610)
- Tiejian Feng (ORCID: https://orcid.org/0000-0001-8217-6269)
- Xiaomin Zhang
- Tong Li (ORCID: https://orcid.org/0000-0001-6269-5117)
- Zhen Zhang (ORCID: https://orcid.org/0000-0001-6188-4792)
- Xiaolu Shi
- Renli Zhang (ORCID: https://orcid.org/0000-0003-0983-6528)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Shenzhen Metro (China) (CN)
- Shenzhen Center for Disease Control and Prevention (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-12-05
- DOI
- https://doi.org/10.3389/fcimb.2025.1703955
- Primary Topic
- Antibiotic Use and Resistance
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Huazhong University of Science and Technology
- Shenzhen University
- Sanming Project of Medicine in Shenzhen