Effects of selenium-mediated RUNX2 overexpression and its transcriptome alterations on Chondrocyte injury in Kashin Beck disease
Micronutrient Se deficiency may contribute to the pathogenesis of KBD by modulating RUNX2 expression and inducing excessive chondrocyte apoptosis, while Se supplementation exerts a protective effect. RUNX2 plays a critical role in KBD progression and may represent a potential therapeutic target.
Authors
- Yongmin Xiong (ORCID: https://orcid.org/0000-0002-8263-2970)
- Shiquan Sun (ORCID: https://orcid.org/0000-0002-9150-6992)
- Di Zhang (ORCID: https://orcid.org/0000-0002-5704-4341)
- Xiaoli Yang (ORCID: https://orcid.org/0000-0002-7172-5995)
- Qiang Li (ORCID: https://orcid.org/0000-0003-4507-1366)
Institutions
- Shaanxi Provincial People's Hospital (CN)
- Second Affiliated Hospital of Xi'an Jiaotong University (CN)
- Xi'an Jiaotong University (CN)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2025-12-05
- DOI
- https://doi.org/10.3389/fcell.2025.1687954
- Primary Topic
- Selenium in Biological Systems
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Fundamental Research Funds for the Central Universities